Glory of the Omega Raider

Of Mice and Manaforges
During the phase where you need to run up to the boss again, there will spawn small mice that you catch by simply moving over them. Once you've done so you get a debuff. You need to play all three intermissions as the number of raid people are split between the phases. So if you're 9 raiders it'll be 3/3/3. They may spawn in the beginning of the corridor when you're in the last part of the corridor.

Time to Vote! Cute or Scary?
Before you pull the boss, target it and either everyone writes /cuddle or /cower. Cowering the boss will make the boss do +15% damage and cuddling the boss will make the boss take -15% less damage.

Mother of All Tantrums
In the four corners of the boss room there's small pads. Click on them during the fight and kill all four ads to get the achievement.

Cheat Meal
During the fight you need to keep one [npc=241923] alive. In the intermission, once the boss reaches 100 energy, you need to drag the [npc=241923] into the blue beam in the middle of the room. Continue progressing the fight without killing the add just yet. In the last phase of the fight the boss will spawn small [npc=242589] adds. Kite the [npc=241923] over these small adds and it'll transform into a Void Forged Echo. You can now kill the add before you kill the boss and you'll get the achievement.

I See... Absolutely Nothing
Outside the boss arena there's a few tents with some boxes next to them. On top of one of the boxes is a blindfold. Everyone in the raid has to pick this item up, and during the boss fight everyone has to click the extra action button and survive for one full minute. The easiest way is to click it at the beginning, and everyone uses it at the same time. After one minute has passed and everyone can see again, you're free to kill the boss and get the achievement.

Breaking the Fourth Wall
Pretty straight forward achievement. Line the walls up so that there's four walls stacked, and then make sure you break the fourth wall 18 times. It doesn't have to be in a row, but make sure you don't accidentally break too many walls in a line, so you make sure to get at least one fourth wall every break-session.

King's Ransom
Walk past the platform that teleports you to the boss, and continue until you see a black swirlie on the edge of the platform. Move closer to it and [npc=218425] will appear. Talk to her and follow the dialogue. This will make her appear in the boss fight. Simply kill the boss like normal to get the achievement. You do need to dodge her classic knife-attack spell.

Defying Gravity
Simply make everyone get lifted up by the [spell=1243577] in Phase 1 during the fight, and you'll get this achievement. Rotate people in and out with the debuff. Very simple and straight forward achievement!

Did my glory run yesterday and here are some general experience (will post achievement specific ones in the comments of the achievements)

* Take a warlock with you to SS a healer, esp. on fractillus and forgeweaver will all those milelong ways to walk
* DO NOT activate raid skip to Nexus King. After you have killed Forgeweaver and entered the area of soul hunters / fractillus there is NO way to get back when you have released after a wipe, because a) there is a wall after plexus and b) the teleport to forgeweaver gets deactivated. Someone activated the skip in our raid and so we had to soft reset the raid after a wipe on fractillus
* There are only ore or two difficult achievements: "Of mice and Manaforge" (Plexus) and "Breaking the Forth Wall" (Fractillus)
* 20 players is fine, but makes "of mice and manaforge" harder. I went with 2/4/14 for more heal on plexus and fractillus and those are the only one where some damage comes in (additional note: we were all between 705 and 710ilvl)

Video Guide on how to get all the Glory of the Omega Raider achievements: https://youtu.be/cAtUHEE79_Y