Systemic Failure

In the Assassination Rogue talent tree, Systemic Failure sits in the Assassination specialization talents, row 7 of 11. It is a single-point node. Its row opens once 8 points are spent in Assassination Talents.

Connected above

The tree draws a line into Systemic Failure from Poison Bomb, Lethal Dose and Flying Daggers or Secondary Poisoning.

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  Poison Bomb

  Envenom has a chance per combo point spent to smash a vial of poison at the target's location, creating a pool of acidic death that deals Nature damage over 2 sec to all enemies within it.

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  Lethal Dose2 ranks

  Your weapon poisons and Nature or Bleed damage over time abilities deal 1% increased damage to targets for each of your lethal poison or damage over time effects on them.

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  Flying Daggers

  Fan of Knives has its radius increased to 12 yds, deals 20% more damage, and an additional 10% when striking 5 or more targets.

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  Secondary Poisoning

  When you apply a Weapon Poison with a single-target attack, you have a 50% chance to strike a nearby enemy for (15% of Attack Power) Physical damage and apply the same Weapon Poison to them.

Connected below

Systemic Failure leads on to Shrouded Suffocation and Blindside.

• 
  Shrouded Suffocation

  Garrote damage increased by 30%. Garrote generates 2 additional combo points when used from Stealth.

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  Blindside

  Ambush and Mutilate have a 10% chance to make your next Ambush free and usable without Stealth. Chance increased to 20% if the target is under 35% health.

Same row

Also on this row: Amplifying Poison and Venomous Wounds.

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  Amplifying Poison

  Coats your weapons with a Lethal Poison that lasts for 60 min. Each strike has a chance to poison the enemy, dealing (8.1% of Attack Power) Nature damage and applying Amplifying Poison for 12 sec. Envenom can consume 10 stacks of Amplifying Poison to deal 35% increased damage.

• 
  Venomous Wounds

  You regain 3 Energy each time your Garrote or Rupture deal Bleed damage to a target affected by your weapon poisons. Energy gain is reduced for bleeds beyond the first. If an enemy dies while afflicted by your Rupture, you regain energy based on its remaining duration.