Lethal Dose

In the Assassination Rogue talent tree, Lethal Dose sits in the Assassination specialization talents, row 6 of 11. It takes 2 points to fill. Its row opens once 8 points are spent in Assassination Talents.

Connected above

The tree draws a line into Lethal Dose from Deathmark and Caustic Spatter.

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  Deathmark

  Carve a deathmark into an enemy, dealing (320% of Attack Power) Bleed damage and restoring 80 Energy to you over 16 sec. Damage dealt to the target by your Garrote, Rupture, and Lethal Poisons is increased by 75%. Each time you apply a Lethal Poison to the target, apply it twice.

• 
  Caustic Spatter

  Envenom or Kingsbane apply Caustic Spatter for 10 sec. Limit 1. Caustic Spatter causes 20% of your Nature damage dealt to splash onto other nearby enemies, reduced beyond 5 targets.

Connected below

Lethal Dose leads on to Venomous Wounds and Systemic Failure.

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  Venomous Wounds

  You regain 3 Energy each time your Garrote or Rupture deal Bleed damage to a target affected by your weapon poisons. Energy gain is reduced for bleeds beyond the first. If an enemy dies while afflicted by your Rupture, you regain energy based on its remaining duration.

• 
  Systemic Failure

  Garrote increases the damage of Ambush and Mutilate on the target by 30%.

Same row

Also on this row: Sanguine Stratagem, Intent to Kill or Iron Wire, Fatal Concoction, Finish the Job or Negotiable Contract, Flying Daggers or Secondary Poisoning and Poison Bomb.

• 
  Sanguine Stratagem

  Gain 1 additional max combo point. Your finishing moves that consume more than 5 combo points have increased effects, and your finishing moves deal 5% increased damage.

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  Intent to Kill

  Shadowstep's cooldown is reduced by 33.3333% when used on a target afflicted by your Garrote.

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  Iron Wire

  Garrotes applied from stealth or during the Improved Garrote window silence their target for 5 sec. Enemies silenced by Garrote deal 15% reduced damage for 5 sec.

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  Fatal Concoction2 ranks

  Increases the damage of your weapon poisons by 20%.

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  Finish the Job

  All damage you deal is increased by 10% while Deathmark is active.

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  Negotiable Contract

  If the target of your Deathmark dies, Deathmark jumps to a nearby enemy combatant for its remaining duration.

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  Flying Daggers

  Fan of Knives has its radius increased to 12 yds, deals 20% more damage, and an additional 10% when striking 5 or more targets.

• 
  Secondary Poisoning

  When you apply a Weapon Poison with a single-target attack, you have a 50% chance to strike a nearby enemy for (15% of Attack Power) Physical damage and apply the same Weapon Poison to them.

• 
  Poison Bomb

  Envenom has a chance per combo point spent to smash a vial of poison at the target's location, creating a pool of acidic death that deals Nature damage over 2 sec to all enemies within it.