Fatal Concoction

In the Assassination Rogue talent tree, Fatal Concoction sits in the Assassination specialization talents, row 6 of 11. It takes 2 points to fill. Its row opens once 8 points are spent in Assassination Talents.

Connected above

The tree draws a line into Fatal Concoction from Bloody Mess and Deathmark.

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  Bloody Mess

  Garrote and Rupture damage increased by 15%.

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  Deathmark

  Carve a deathmark into an enemy, dealing (320% of Attack Power) Bleed damage and restoring 80 Energy to you over 16 sec. Damage dealt to the target by your Garrote, Rupture, and Lethal Poisons is increased by 75%. Each time you apply a Lethal Poison to the target, apply it twice.

Connected below

Fatal Concoction leads on to Amplifying Poison and Venomous Wounds.

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  Amplifying Poison

  Coats your weapons with a Lethal Poison that lasts for 60 min. Each strike has a chance to poison the enemy, dealing (8.1% of Attack Power) Nature damage and applying Amplifying Poison for 12 sec. Envenom can consume 10 stacks of Amplifying Poison to deal 35% increased damage.

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  Venomous Wounds

  You regain 3 Energy each time your Garrote or Rupture deal Bleed damage to a target affected by your weapon poisons. Energy gain is reduced for bleeds beyond the first. If an enemy dies while afflicted by your Rupture, you regain energy based on its remaining duration.

Same row

Also on this row: Sanguine Stratagem, Intent to Kill or Iron Wire, Finish the Job or Negotiable Contract, Lethal Dose, Flying Daggers or Secondary Poisoning and Poison Bomb.

• 
  Sanguine Stratagem

  Gain 1 additional max combo point. Your finishing moves that consume more than 5 combo points have increased effects, and your finishing moves deal 5% increased damage.

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  Intent to Kill

  Shadowstep's cooldown is reduced by 33.3333% when used on a target afflicted by your Garrote.

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  Iron Wire

  Garrotes applied from stealth or during the Improved Garrote window silence their target for 5 sec. Enemies silenced by Garrote deal 15% reduced damage for 5 sec.

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  Finish the Job

  All damage you deal is increased by 10% while Deathmark is active.

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  Negotiable Contract

  If the target of your Deathmark dies, Deathmark jumps to a nearby enemy combatant for its remaining duration.

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  Lethal Dose2 ranks

  Your weapon poisons and Nature or Bleed damage over time abilities deal 1% increased damage to targets for each of your lethal poison or damage over time effects on them.

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  Flying Daggers

  Fan of Knives has its radius increased to 12 yds, deals 20% more damage, and an additional 10% when striking 5 or more targets.

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  Secondary Poisoning

  When you apply a Weapon Poison with a single-target attack, you have a 50% chance to strike a nearby enemy for (15% of Attack Power) Physical damage and apply the same Weapon Poison to them.

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  Poison Bomb

  Envenom has a chance per combo point spent to smash a vial of poison at the target's location, creating a pool of acidic death that deals Nature damage over 2 sec to all enemies within it.