Sanguine Stratagem

In the Assassination Rogue talent tree, Sanguine Stratagem sits in the Assassination specialization talents, row 6 of 11. It is a single-point node. Its row opens once 8 points are spent in Assassination Talents.

Connected above

The tree draws a line into Sanguine Stratagem from Bloody Mess.

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  Bloody Mess

  Garrote and Rupture damage increased by 15%.

Connected below

Sanguine Stratagem leads on to Amplifying Poison.

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  Amplifying Poison

  Coats your weapons with a Lethal Poison that lasts for 60 min. Each strike has a chance to poison the enemy, dealing (8.1% of Attack Power) Nature damage and applying Amplifying Poison for 12 sec. Envenom can consume 10 stacks of Amplifying Poison to deal 35% increased damage.

Same row

Also on this row: Intent to Kill or Iron Wire, Fatal Concoction, Finish the Job or Negotiable Contract, Lethal Dose, Flying Daggers or Secondary Poisoning and Poison Bomb.

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  Intent to Kill

  Shadowstep's cooldown is reduced by 33.3333% when used on a target afflicted by your Garrote.

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  Iron Wire

  Garrotes applied from stealth or during the Improved Garrote window silence their target for 5 sec. Enemies silenced by Garrote deal 15% reduced damage for 5 sec.

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  Fatal Concoction2 ranks

  Increases the damage of your weapon poisons by 20%.

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  Finish the Job

  All damage you deal is increased by 10% while Deathmark is active.

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  Negotiable Contract

  If the target of your Deathmark dies, Deathmark jumps to a nearby enemy combatant for its remaining duration.

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  Lethal Dose2 ranks

  Your weapon poisons and Nature or Bleed damage over time abilities deal 1% increased damage to targets for each of your lethal poison or damage over time effects on them.

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  Flying Daggers

  Fan of Knives has its radius increased to 12 yds, deals 20% more damage, and an additional 10% when striking 5 or more targets.

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  Secondary Poisoning

  When you apply a Weapon Poison with a single-target attack, you have a 50% chance to strike a nearby enemy for (15% of Attack Power) Physical damage and apply the same Weapon Poison to them.

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  Poison Bomb

  Envenom has a chance per combo point spent to smash a vial of poison at the target's location, creating a pool of acidic death that deals Nature damage over 2 sec to all enemies within it.