DANGER: Bestrix

This Spider Mob is on the Isle of the Watchers, in the cave where all those elite spiders are. In order to avoid that area though, you can go towards the tower on the island and then jump to the spider area and walk on the rooftop of the spider cave. when you are near Bestrix you can jump down and tag her. Careful though, she or other spiders nearby puts you in a web for 24 secs and if no1 else is there to release you, you will most certainly be dead when all other spiders corner you.
Once you are done and free, walk outside and with a glider you can fly away from the cave :)

Most of people goes to Warden's Redoubt Flight Point but actually I prefer use Watcher's Aerie FP, take the little path to the right (behind the Owl Statue) this will bring you to the top of the huge rock over the spiders area and then use eng Goblin Glider or Goblin Glider Kit or [item=131811] or just jump if you feel like killing some more mobs.
Happy Hunting!

[npc=111454] is located in Azsuna.
Coordinates: 41.8, 88.2 - Azsuna, Isle of the Watchers
TomTom: /way Azsuna 41.8, 88.2 Bestrix
Flight point: Wardens' Redoubt - [npc=108888]

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• if you start from "Wardens' Redoubt", follow the path to the west on the "Isle of the Watchers". Walk past [npc=111763], where the cave is on the left, and go up the path. Stay on your way up until you reach a passage where some Venomspinner are located. Go the way up to the spiders and you'll see [npc=111454] hanging on the ceiling.
  
  - if you get into a net during the fight, try to get out of it.
  
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World Quest:
DANGER: Bestrix
[quest=43961]

I show you the way to [npc=111454] in this Video: https://youtu.be/rpy5kGZ6D3U